Het-PDB Navi2 (PDB: 3G9L)

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Ligands
Code	Name		Style	Show	Link
J67	(3z)-1-[(6-fluoro-4h-1,3-benzodioxin-8-yl)methyl]-4-[(E)-2-phenylethenyl]-1h-indole-2,3-dione 3-oxime				PoSSuM

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Glycosylation
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Download interaction data: 3G9L

Code :

3G9L PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

JNK3 bound to (Z)-1-((6-fluoro-4H-benzo[D][1,3]dioxin-8-yl)methyl)-3-(hydroxyimino)-4-styrylindolin-2-one

Release Data :

2009-04-28

Compound :

mol_id	molecule	chains	synonym
1	Mitogen-activated protein kinase 10	X	Stress-activated protein kinase JNK3, c-Jun N-terminal kinase 3, MAP kinase p49 3F12
	ec: 2.7.11.24 fragment: kinase domain

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: JNK3, JNK3A, MAPK10, PRKM10 expression_system_strain: BL21(DE3) expression_system_vector_type: plasmid expression_system_plasmid: pET-15B

Authors :

Jacobs, M.D.

Keywords :

kinase, inhibitor, phosphorylation, ATP-binding, Epilepsy, Nucleotide-binding, Phosphoprotein, Serine/threonine-protein kinase, Transferase

Exp. method :

X-RAY DIFFRACTION ( 2.20 Å )

Citation :

Structure-based design and parallel synthesis of N-benzyl isatin oximes as JNK3 MAP kinase inhibitors.

Cao, J.,Gao, H.,Bemis, G. et al.
(2009) Bioorg.Med.Chem.Lett. 19 : 2891 - 2895

Chain :

UniProt :

P53779 (MK10_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]	2.7.11.24	-
	-	-
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]	2.7.11.24	-
	-	-

PDB ID: 3G9L