Brand  (β version)

PDB ID: 3G76

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Ligands
Code Name Style Show Link
ZN Zinc ion PoSSuM
CZ3 1,1'-{hexa-2,4-diyne-1,6-diylbis[oxy{(2s,3r)-2-[(N-methyl-L-alanyl)amino]-1-oxobutane-3,1-diyl}(2s)pyrrolidine-1,2-diylmethanediyl]}bis[5-(phenylsulfanyl)-1h-tetrazole] PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3G76   PDBj   RCSB PDB   PDBe
Header : LIGASE
Title : Crystal structure of XIAP-BIR3 in complex with a bivalent compound
Release Data : 2009-05-12
Compound :
mol_id molecule chains synonym
1 Baculoviral IAP repeat-containing protein 4 A,B,C,D,E,F,G,H E3 ubiquitin-protein ligase XIAP, Inhibitor of apoptosis protein 3, X-linked inhibitor of apoptosis protein, X-linked IAP, IAP-like protein, HILP
ec: 6.3.2.-
fragment: BIR3 domain, UNP residues 241-356
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: XIAP
expression_system_vector_type: plasmid
Authors : Cossu, F., Milani, M., Mastrangelo, E., Bolognesi, M.
Keywords : Apoptosis, IAP, SmacDIABLO, peptidomimetics, pro-apoptotic drugs, Cytoplasm, Ligase, Metal-binding, Phosphoprotein, Polymorphism, Protease inhibitor, Thiol protease inhibitor, Ubl conjugation, Ubl conjugation pathway, Zinc, Zinc-finger
Exp. method : X-RAY DIFFRACTION ( 3.000 Å )
Citation :

Structural basis for bivalent smac-mimetics recognition in the IAP protein family

Cossu, F.,Milani, M.,Mastrangelo, E.  et al.
(2009)  J.Mol.Biol.  392 : 630 - 644

PubMed: 19393243
DOI: 10.1016/j.jmb.2009.04.033

Reaction

Chain : A, B, C, D, E, F, G, H
UniProt : P98170 (XIAP_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. 2.3.2.27 PubMed:19473982, PubMed:20154138, PubMed:21931591, PubMed:22304967, PubMed:22607974, PubMed:30026309
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