Brand  (β version)

PDB ID: 3G60

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Ligands
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0JZ (4r,11r,18r)-4,11,18-tri(propan-2-yl)-6,13,20-triselena-3,10,17,22,23,24-hexaazatetracyclo[17.2.1.1~5,8~.1~12,15~]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione PoSSuM
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Structure summary

Code : 3G60   PDBj   RCSB PDB   PDBe
Header : MEMBRANE PROTEIN
Title : Structure of P-glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding
Release Data : 2009-03-24
Compound :
mol_id molecule chains synonym
1 Multidrug resistance protein 1a A,B MCG1178
Source :
mol_id organism_scientific organism_common
1 Mus musculus  (taxid:10090) Mouse
gene: Abcb1a, mCG_1178
Authors : Aller, S.G., Yu, J., Ward, A., Weng, Y., Chittaboina, S., Zhuo, R., Harrell, P.M., Trinh, Y.T., Zhang, Q., Urbatsch, I.L., Chang, G.
Keywords : P-glycoprotein, Pgp, multidrug resistance, membrane protein, cyclic peptide
Exp. method : X-RAY DIFFRACTION ( 4.40 Å )
Citation :

Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding.

Aller, S.G.,Yu, J.,Ward, A.  et al.
(2009)  Science  323 : 1718 - 1722

PubMed: 19325113
DOI: 10.1126/science.1168750

Reaction

Chain : A, B
UniProt : Q5I1Y5 (MDR1A_MOUSE)
Reaction: EC: Evidence:
Physiological Direction:
ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2. 7.6.2.2 UniProtKB:P08183
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ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2. 7.6.2.1 PubMed:8898203
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a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ADP + H(+) + phosphate - PubMed:8898203
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a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + H(+) + phosphate - PubMed:8898203
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a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ATP + H2O = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ADP + H(+) + phosphate - PubMed:8898203
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a sphingomyelin(in) + ATP + H2O = a sphingomyelin(out) + ADP + H(+) + phosphate - PubMed:8898203
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