Het-PDB Navi2 (PDB: 3G45)

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Ligands
Code	Name	Link
ZN	Zinc ion	PoSSuM
MG	Magnesium ion	PoSSuM
988	8-(3-nitrophenyl)-6-(pyridin-4-ylmethyl)quinoline	PoSSuM

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Download interaction data: 3G45

Code :

3G45 PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Crystal structure of human phosphodiesterase 4b with regulatory domain and d155988

Release Data :

2010-01-19

Compound :

mol_id	molecule	chains	synonym
1	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	A,B	DPDE4, PDE32
	ec: 3.1.4.17 fragment: S241 CLOOP, residues 241-289 and 305-659

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: PDE4B, DPDE4

Authors :

Staker, B.L.

Keywords :

phosphodiesterase, Alternative splicing, cAMP, Hydrolase, Phosphoprotein, Polymorphism

Exp. method :

X-RAY DIFFRACTION ( 2.63 Å )

Citation :

Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety.

Burgin, A.B.,Magnusson, O.T.,Singh, J. et al.
(2010) Nat.Biotechnol. 28 : 63 - 70

Chain :

A, B

UniProt :

Q07343 (PDE4B_HUMAN)

PDB ID: 3G45