Brand  (β version)

color scheme of protein:


interaction residue:

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Code Name Link
U Uridine-5'-monophosphate
Code : 3G1D
Header : LYASE
Title : Crystal structure of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with uridine 5'-monophosphate
Release Data : 2009-06-23
Compound :
mol_id molecule chains synonym
1 Orotidine 5'-phosphate decarboxylase A,B OMP decarboxylase, OMPDCase, OMPdecase
mutation: R101P
Source :
mol_id organism_scientific expression_system
1 Methanothermobacter thermautotrophicus str. Delta H  (taxid:187420) Escherichia coli  (taxid:562)
gene: pyrF, MTH_129
Authors : Fedorov, A.A., Fedorov, E.V., Chan, K.K., Gerlt, J.A., Almo, S.C.
Keywords : orotidine 5'-monophosphate decarboxylase, UMP, Decarboxylase, Pyrimidine biosynthesis, LYASE
Exp. method : X-RAY DIFFRACTION ( 1.5 Å )
Citation :

Mechanism of the orotidine 5'-monophosphate decarboxylase-catalyzed reaction: evidence for substrate destabilization.

Chan, K.K.,Wood, B.M.,Fedorov, A.A.  et al.
(2009)  Biochemistry  48 : 5518 - 5531

PubMed: 19435314
DOI: 10.1021/bi900623r

Chain : A, B
UniProt : O26232 (PYRF_METTH)
Reaction : Orotidine 5'-phosphate = UMP + CO(2).