Brand  (β version)

PDB ID: 3FXZ

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Ligands
Code Name Style Show Link
FLL Octahedral ru-pyridocarbazole PoSSuM
Non-standard Residues
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TPO Phosphothreonine
Glycosylation
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Modification
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Structure summary

Code : 3FXZ   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of PAK1 kinase domain with ruthenium complex lambda-FL172
Release Data : 2009-02-17
Compound :
mol_id molecule chains synonym
1 Serine/threonine-protein kinase PAK 1 A p21-activated kinase 1, PAK-1, p65-PAK, Alpha-PAK
ec: 2.7.11.1
fragment: UNP residues 249-545
mutation: K299R
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: PAK1
expression_system_strain: BL21(DE3)
expression_system_vector_type: Plasmid
expression_system_plasmid: pET151/D-TOPO
Authors : Maksimoska, J., Marmorstein, R., Meggers, E.
Keywords : Transferase, Kinase, ATP-binding, Phosphorylation, Allosteric enzyme, Alternative splicing, Apoptosis, Cell junction, Cytoplasm, Nucleotide-binding, Phosphoprotein, Polymorphism, Serine/threonine-protein kinase
Exp. method : X-RAY DIFFRACTION ( 1.64 Å )
Citation :

Targeting Large Kinase Active Site with Rigid, Bulky Octahedral Ruthenium Complexes

Maksimoska, J.,Feng, L.,Harms, K.  et al.
(2008)  J.Am.Chem.Soc.  130 : 15764 - 15765

PubMed: 18973295

Reaction

Chain : A
UniProt : Q13153 (PAK1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:10551809, PubMed:20417602, PubMed:22153498, PubMed:9032240
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 PubMed:10551809, PubMed:22153498, PubMed:9032240
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