Brand  (β version)

PDB ID: 3FV8

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Ligands
Code Name Style Show Link
EDO 1,2-ethanediol PoSSuM
JK3 5-bromo-N-(3-chloro-2-(4-(prop-2-ynyl)piperazin-1-yl)phenyl)furan-2-carboxamide PoSSuM
Non-standard Residues
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OCY Hydroxyethylcysteine
Glycosylation
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Structure summary

Code : 3FV8   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : JNK3 bound to piperazine amide inhibitor, SR2774.
Release Data : 2009-04-07
Compound :
mol_id molecule chains synonym
1 Mitogen-activated protein kinase 10 A Stress-activated protein kinase JNK3, c-Jun N-terminal kinase 3, MAP kinase p49 3F12
ec: 2.7.11.24
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: JNK3, JNK3A, MAPK10, PRKM10
expression_system_strain: BL21(DE3)
expression_system_vector_type: Plasmid
expression_system_plasmid: pDEST 14
Authors : Habel, J.E.
Keywords : JNK3, protein-inhibitor complex, Alternative splicing, ATP-binding, Chromosomal rearrangement, Cytoplasm, Epilepsy, Kinase, Nucleotide-binding, Phosphoprotein, Serine/threonine-protein kinase, Transferase
Exp. method : X-RAY DIFFRACTION ( 2.280 Å )
Citation :

Synthesis and SAR of piperazine amides as novel c-jun N-terminal kinase (JNK) inhibitors.

Shin, Y.,Chen, W.,Habel, J.  et al.
(2009)  Bioorg.Med.Chem.Lett.  19 : 3344 - 3347

PubMed: 19433357
DOI: 10.1016/j.bmcl.2009.03.086

Reaction

Chain : A
UniProt : P53779 (MK10_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.24 -
-
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.24 -
-