Brand  (β version)

PDB ID: 3FU3

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Ligands
Code Name Style Show Link
92G 4-(2-amino-1,3-thiazol-4-yl)phenol PoSSuM
ACT Acetate ion PoSSuM
IMD Imidazole PoSSuM
YB Ytterbium (III) ion PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3FU3   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Leukotriene A4 hydrolase in complex with fragment 4-(2-amino-1,3-thiazol-4-yl)phenol
Release Data : 2009-07-28
Compound :
mol_id molecule chains synonym
1 Leukotriene A-4 hydrolase A Leukotriene A(4) hydrolase, LTA-4 hydrolase
ec: 3.3.2.6
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: LTA4H, LTA4
expression_system_strain: BL21-AI/pRARE
expression_system_vector_type: plasmid
Authors : Davies, D.R.
Keywords : Leukotriene A4 Hydrolase, LTA4H, Fragment crystallography, Fragments of Life, FOL, Alternative splicing, Cytoplasm, Hydrolase, Leukotriene biosynthesis, Metal-binding, Metalloprotease, Multifunctional enzyme, Polymorphism, Protease, Zinc
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography.

Davies, D.R.,Mamat, B.,Magnusson, O.T.  et al.
(2009)  J.Med.Chem.  52 : 4694 - 4715

PubMed: 19618939
DOI: 10.1021/jm900259h

Reaction

Chain : A
UniProt : P09960 (LKHA4_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
leukotriene A4 + H2O = leukotriene B4 3.3.2.6 PubMed:11675384, PubMed:11917124, PubMed:12207002, PubMed:15078870, PubMed:18804029, PubMed:1897988, PubMed:24591641, PubMed:6490615, PubMed:7667299, PubMed:9395533
left-to-right PubMed:11917124
(5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)- eicosapentaenoate + H2O = resolvin E1 - PubMed:21206090
left-to-right
(5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)- eicosapentaenoate + H2O = 18S-resolvin E1 - PubMed:21206090
left-to-right
Release of the N-terminal residue from a tripeptide. 3.4.11.4 PubMed:11675384, PubMed:11917124, PubMed:20813919, PubMed:24591641, PubMed:9395533
-
Cofactor: Evidence: Note:
Zn(2+) ECO:0000269 | PubMed:11175901
ECO:0000269 | PubMed:12207002
ECO:0000269 | PubMed:15078870
ECO:0000269 | PubMed:18804029
ECO:0000269 | PubMed:24591641
Binds 1 zinc ion per subunit.