Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
FSS 3-(2,6-dichlorophenyl)-7-({4-[(diethylamino)methoxy]phenyl}amino)-1-methyl-3,4-dihydropyrimido[4,5-D]pyrimidin-2(1h)-one
Code : 3FSF
Header : SIGNALING PROTEIN, TRANSFERASE
Title : P38 kinase crystal structure in complex with 3-(2,6-Dichloro-phenyl)-7-[4-(2-diethylamino-ethoxy)-phenylamino]-1-methyl-3,4-dihydro-1H-pyrimido[4,5-D]pyrimidin-2-one
Release Data : 2009-12-22
Compound :
mol_id molecule chains synonym
1 Mitogen-activated protein kinase 14 A Mitogen-activated protein kinase p38 alpha, MAP kinase p38 alpha, Cytokine suppressive anti-inflammatory drug-binding protein, CSAID-binding protein, CSBP, MAX-interacting protein 2, MAP kinase MXI2, SAPK2A
ec: 2.7.11.24
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: CSBP, CSBP1, CSBP2, CSPB1, MAPK14, MXI2
Authors : Kuglstatter, A., Bertrand, J., Lovejoy, B.
Keywords : P38; MAP KINASE; SERINE/THREONINE KINASE, Alternative splicing, ATP-binding, Cytoplasm, Kinase, Nucleotide-binding, Nucleus, Phosphoprotein, Polymorphism, Serine/threonine-protein kinase, Transferase, SIGNALING PROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.10 Å )
Citation :

The Discovery of Pamapimod and R1487 as Orally Bioavailable and Highly Selective Inhibitors of p38 Map Kinase

Soth, M.,Kuglstatter, A.,Goldstein, D.
To be Published 

Chain : A
UniProt : Q16539 (MK14_HUMAN)
Reaction : ATP + a protein = ADP + a phosphoprotein.