Brand  (β version)

PDB ID: 3FR4

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Ligands
Code Name Style Show Link
F8A 9-[2-(trifluoromethyl)benzyl]-2,3,4,9-tetrahydro-1h-carbazole-8-carboxylic acid PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3FR4   PDBj   RCSB PDB   PDBe
Header : LIPID BINDING PROTEIN
Title : N-Benzyl-indolo carboxylic acids: Design and synthesis of potent and selective adipocyte Fatty-Acid Binding Protein (A-FABP) inhibitors
Release Data : 2009-03-10
Compound :
mol_id molecule chains synonym
1 Fatty acid-binding protein, adipocyte A A-FABP, AFABP, Fatty acid-binding protein 4, Adipocyte lipid-binding protein, ALBP
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: FABP4
Authors : Barf, T., Hammer, K., Lehmann, F., Haile, S., Axen, E., Medina, C., Uppenberg, J., Svensson, S., Rondahl, L., Lundb ck, T.
Keywords : selective adipocyte Fatty-Acid Binding Protein (A-FABP) inhibitors, Cytoplasm, Lipid-binding, Nucleus, Phosphoprotein, Polymorphism, Transport, LIPID BINDING PROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.16 Å )
Citation :

N-Benzyl-indolo carboxylic acids: Design and synthesis of potent and selective adipocyte fatty-acid binding protein (A-FABP) inhibitors.

Barf, T.,Lehmann, F.,Hammer, K.  et al.
(2009)  Bioorg.Med.Chem.Lett.  19 : 1745 - 1748

PubMed: 19217286
DOI: 10.1016/j.bmcl.2009.01.084

Reaction

Chain : A
UniProt : P15090 (FABP4_HUMAN)
Reaction : -