Brand  (β version)

PDB ID: 3FJL

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Ligands
Code Name Style Show Link
ACY Acetic acid PoSSuM
CJH (2z)-2-cyano-N-(3'-ethoxybiphenyl-4-yl)-3-hydroxybut-2-enamide PoSSuM
FMN Flavin mononucleotide PoSSuM
ORO Orotic acid PoSSuM
SO4 Sulfate ion PoSSuM
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Structure summary

Code : 3FJL   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 3
Release Data : 2009-06-09
Compound :
mol_id molecule chains synonym
1 Dihydroorotate dehydrogenase A DHOdehase, Dihydroorotate oxidase
ec: 1.3.3.1
fragment: residues 30-396
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
Authors : Heikkila, T.
Keywords : Alpha-Beta Barrel, TIM Barrel, FAD, Flavoprotein, Membrane, Mitochondrion, Mitochondrion inner membrane, Oxidoreductase, Polymorphism, Pyrimidine biosynthesis, Transit peptide
Exp. method : X-RAY DIFFRACTION ( 1.90 Å )
Citation :

Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases

Davies, M.,Heikkila, T.,McConkey, G.A.  et al.
(2009)  J.Med.Chem.  52 : 2683 - 2693

PubMed: 19351152
DOI: 10.1021/jm800963t

Reaction

Chain : A
UniProt : Q02127 (PYRD_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
(S)-dihydroorotate + a quinone = orotate + a quinol 1.3.5.2 PubMed:8925840
-
Cofactor: Evidence: Note:
FMN ECO:0000269 | PubMed:10673429
Binds 1 FMN per subunit.