Brand  (β version)

PDB ID: 3FI2

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Ligands
Code Name Style Show Link
EDO 1,2-ethanediol PoSSuM
JK1 3-{4-[(phenylcarbamoyl)amino]-1h-pyrazol-1-yl}-N-(3,4,5-trimethoxyphenyl)benzamide PoSSuM
Non-standard Residues
Code Name Show
OCY Hydroxyethylcysteine
Glycosylation
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Structure summary

Code : 3FI2   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of JNK3 with amino-pyrazole inhibitor, SR-3451
Release Data : 2009-03-03
Compound :
mol_id molecule chains synonym
1 Mitogen-activated protein kinase 10 A Stress-activated protein kinase JNK3, c-Jun N-terminal kinase 3, MAP kinase p49 3F12
ec: 2.7.11.24
fragment: UNP residues 39-402
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: JNK3, JNK3A, MAPK10, PRKM10
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pDEST14
Authors : Habel, J.E.
Keywords : JNK3, protein-inhibitor complex, Alternative splicing, ATP-binding, Chromosomal rearrangement, Cytoplasm, Epilepsy, Kinase, Nucleotide-binding, Phosphoprotein, Serine/threonine-protein kinase, Transferase
Exp. method : X-RAY DIFFRACTION ( 2.28 Å )
Citation :

Structure-activity relationships and X-ray structures describing the selectivity of aminopyrazole inhibitors for c-Jun N-terminal kinase 3 (JNK3) over p38.

Kamenecka, T.,Habel, J.,Duckett, D.  et al.
(2009)  J.Biol.Chem.  284 : 12853 - 12861

PubMed: 19261605
DOI: 10.1074/jbc.M809430200

Reaction

Chain : A
UniProt : P53779 (MK10_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.24 -
-
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.24 -
-