PDB ID: 3FFG
Hetero Atom Contents
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FFG | (R)-6-(2'-((3-hydroxypyrrolidin-1-yl)methyl)biphenyl-4-yl)-1-(3-(5-oxo-4,5-dihydro-1h-1,2,4-triazol-3-yl)phenyl)-3-(trifluoromethyl)-5,6-dihydro-1h-pyrazolo[3,4-C]pyridin-7(4h)-one | PoSSuM |
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Download interaction data: 3FFG
Structure summary
Code : | 3FFG PDBj RCSB PDB PDBe | ||||||||||||||||||||||||
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Header : | HYDROLASE | ||||||||||||||||||||||||
Title : | Factor XA in complex with the inhibitor (R)-6-(2'-((3- HYDROXYPYRROLIDIN-1-YL)METHYL)BIPHENYL-4-YL)-1-(3-(5-OXO-4,5-DIHYDRO-1H-1,2,4-TRIAZOL-3-YL)PHENYL)-3-(TRIFLUOROMETHYL)-5,6-DIHYDRO-1H-PYRAZOLO[3,4-C]PYRIDIN- 7(4H)-ONE | ||||||||||||||||||||||||
Release Data : | 2009-12-08 | ||||||||||||||||||||||||
Compound : |
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Source : |
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Authors : | Alexander, R.A. | ||||||||||||||||||||||||
Keywords : | GLYCOPROTEIN, HYDROLASE, SERINE PROTEASE, PLASMA, BLOOD COAGULATION FACTOR, PROTEIN INHIBITOR COMPLEX, CALCIUM- BINDING, Blood coagulation, Calcium, Cleavage on pair of basic residues, Protease, Secreted | ||||||||||||||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.540 Å ) | ||||||||||||||||||||||||
Citation : |
Phenyltriazolinones as potent factor Xa inhibitors.
Quan, M.L.,Pinto, D.J.,Rossi, K.A.
et al.
PubMed: 20100660 |
Reaction
Chain : | L | ||||||||
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UniProt : | P00742 (FA10_HUMAN) | ||||||||
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