Brand  (β version)

PDB ID: 3FEJ

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Ligands
Code Name Style Show Link
CTM (2s)-3-(4-{[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methoxy}-2-methylphenyl)-2-ethoxypropanoic acid PoSSuM
Non-standard Residues
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Structure summary

Code : 3FEJ   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION
Title : Design and biological evaluation of novel, balanced dual PPARa/G agonists
Release Data : 2009-10-20
Compound :
mol_id molecule chains synonym
1 Peroxisome proliferator-activated receptor gamma A PPAR-gamma, Nuclear receptor subfamily 1 group C member 3
fragment: PPAR gamma ligand binding domain
mol_id molecule chains synonym
2 peptide motif 3 of Nuclear receptor coactivator 1 B SRC-1 Coactivator protein peptide motif 3
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: PPARG, NR1C3
mol_id organism_scientific
2
synthetic: yes
other_details: Chemically synthesis
Authors : Benz, J., Grether, U., Gsell, B., Binggeli, A., Hilpert, H., Kuhn, B., Maerki, H.P., Mohr, P., Ruf, A., Stihle, M.
Keywords : Nuclear Recpetor, Transcription factor, Diabetes, Activator, Alternative splicing, Diabetes mellitus, Disease mutation, DNA-binding, Metal-binding, Nucleus, Obesity, Phosphoprotein, Polymorphism, Receptor, Transcription, Transcription regulation, Zinc, Zinc-finger
Exp. method : X-RAY DIFFRACTION ( 2.01 Å )
Citation :

Design and biological evaluation of novel, balanced dual PPARalpha/gamma agonists

Grether, U.,Benardeau, A.,Benz, J.  et al.
(2009)  Chemmedchem  4 : 951 - 956

PubMed: 19326383
DOI: 10.1002/cmdc.200800425

Reaction

Chain : A
UniProt : P37231 (PPARG_HUMAN)
Reaction : -
Chain : B
UniProt : Q15788 (NCOA1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+) 2.3.1.48 -
-