Brand  (β version)

PDB ID: 3F2N

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Ligands
Code Name Style Show Link
EDO 1,2-ethanediol PoSSuM
IZZ (2s)-2-{[3-(3-aminophenyl)imidazo[1,2-B]pyridazin-6-yl]amino}-3-methylbutan-1-ol PoSSuM
PO4 Phosphate ion PoSSuM
Non-standard Residues
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Structure summary

Code : 3F2N   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal Structure of Human Haspin with an Imidazo-pyridazine ligand
Release Data : 2008-12-02
Compound :
mol_id molecule chains synonym
1 Serine/threonine-protein kinase haspin A GSG2, Haploid germ cell-specific nuclear protein kinase, H-haspin, Germ cell-specific gene 2 protein
ec: 2.7.11.1
fragment: Protein kinase, residues 471-798
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: HASPIN
expression_system_strain: BL21(DE3)-R3
expression_system_vector_type: Plasmid
expression_system_plasmid: pNIC28-Bsa4
Authors : Filippakopoulos, P., Eswaran, J., Keates, T., Burgess-Brown, N., Fedorov, O., Yue, W.W., Murray, J.W., Pike, A.C.W., Von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Keywords : Haspin, Germ cell associated 2, haploid germ cell specific nuclear protein kinase, ATP-binding, Cell cycle, Chromatin regulator, Kinase, Magnesium, Nucleotide-binding, Nucleus, Phosphoprotein, Serine/threonine-protein kinase, Transferase, Structural Genomics, Structural Genomics Consortium, SGC
Exp. method : X-RAY DIFFRACTION ( 1.80 Å )
Citation :

Crystal Structure of Human Haspin with an Imidazo-pyridazine ligand

Filippakopoulos, P.,Eswaran, J.,Keates, T.  et al.
To be Published 

Reaction

Chain : A
UniProt : Q8TF76 (HASP_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:19918049, PubMed:19918057
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 PubMed:19918049, PubMed:19918057
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