Brand  (β version)

color scheme of protein:

hetatm:

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information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
CL Chloride ion
MG Magnesium ion
PI Hydrogenphosphate ion
ADP Adenosine-5'-diphosphate
Code : 3ETJ
Header : LYASE
Title : Crystal structure E. coli Purk in complex with Mg, ADP, and Pi
Release Data : 2008-10-21
Compound :
mol_id molecule chains synonym
1 Phosphoribosylaminoimidazole carboxylase ATPase subunit A,B AIR carboxylase, AIRC
ec: 4.1.1.21
mutation: E61Q, Q205R
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:83333) Escherichia coli  (taxid:562)
strain: K12
gene: b0522, JW0511, purK, PURK_ECOLI
expression_system_strain: HMS174(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET31
Authors : Holden, H.M., Thoden, J.B.
Keywords : ATP-grasp, purine biosynthesis, antimicrobial, ATP-binding, Decarboxylase, Lyase, Nucleotide-binding
Exp. method : X-RAY DIFFRACTION ( 1.60 Å )
Citation :

Structural analysis of the active site geometry of N(5)-Carboxyaminoimidazole ribonucleotide synthetase from Escherichia coli.

Thoden, J.B.,Holden, H.M.,Firestine, S.M.
(2008)  Biochemistry  47 : 13346 - 13353

PubMed: 19053251
DOI: 10.1021/bi801734z

Chain : A, B
UniProt : P09029 (PURK_ECOLI)
Reaction : ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO(3)(-) = ADP + phosphate + 5-carboxyamino-1-(5-phospho-D- ribosyl)imidazole.