Brand  (β version)

PDB ID: 3EPW

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
CA Calcium ion PoSSuM
JMQ 7-(((2r,3r,4s)-3,4-dihydroxy-2-(hydroxymethyl)pyrrolidin-1-yl)methyl)-3h-pyrrolo[3,2-D]pyrimidin-4(5h)-one PoSSuM
MG Magnesium ion PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 3EPW   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal structure of Trypanosoma vivax nucleoside hydrolase in complex with the inhibitor (2R,3R,4S)-1-[(4-hydroxy-5H-pyrrolo[3,2-D]pyrimidin-7-yl)methyl]-2-(hydroxymethyl)pyrrolidin-3,4-diol
Release Data : 2009-03-24
Compound :
mol_id molecule chains
1 IAG-nucleoside hydrolase A,B
ec: 3.2.2.1
Source :
mol_id organism_scientific expression_system
1 Trypanosoma vivax  (taxid:5699) Escherichia coli  (taxid:562)
expression_system_strain: WK6
expression_system_vector_type: plasmid
expression_system_plasmid: pQE-30
Authors : Versees, W., Goeminne, A., Berg, M., Vandemeulebroucke, A., Haemers, A., Augustyns, K., Steyaert, J.
Keywords : Rossmann fold, active site loops, aromatic stacking, Hydrolase
Exp. method : X-RAY DIFFRACTION ( 1.30 Å )
Citation :

Crystal structures of T. vivax nucleoside hydrolase in complex with new potent and specific inhibitors.

Versees, W.,Goeminne, A.,Berg, M.  et al.
(2009)  Biochim.Biophys.Acta  1794 : 953 - 960

PubMed: 19281874
DOI: 10.1016/j.bbapap.2009.02.011

Reaction

Chain : A, B
UniProt : Q9GPQ4 (Q9GPQ4_TRYVI)
Reaction : -