Brand  (β version)

PDB ID: 3E65

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Ligands
Code Name Style Show Link
HEM Protoporphyrin ix containing Fe PoSSuM
H4B 5,6,7,8-tetrahydrobiopterin PoSSuM
XXZ 1-[4-(aminomethyl)benzoyl]-5'-fluoro-1'H-spiro[piperidine-4,2'-quinazolin]-4'-amine PoSSuM
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Structure summary

Code : 3E65   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Murine INOS dimer with HEME, pterin and inhibitor AR-C120011
Release Data : 2008-10-07
Compound :
mol_id molecule chains synonym
1 Nitric oxide synthase, inducible A,B Inducible NO synthase, Inducible NOS, iNOS, NOS type II, Macrophage NOS, MAC-NOS
ec: 1.14.13.39
fragment: oxygenase domain (UNP residues 77-496)
Source :
mol_id organism_scientific organism_common expression_system
1 Mus musculus  (taxid:10090) Mouse Escherichia coli  (taxid:562)
gene: Nos2, Inosl
Authors : Rosenfeld, R.J., Garcin, E.D., Getzoff, E.D.
Keywords : dimer, inducible nitric oxide synthase, Calmodulin-binding, FAD, FMN, Heme, Iron, Metal-binding, NADP, Oxidoreductase, Polymorphism, Zinc
Exp. method : X-RAY DIFFRACTION ( 2.05 Å )
Citation :

Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase.

Garcin, E.D.,Arvai, A.S.,Rosenfeld, R.J.  et al.
(2008)  Nat.Chem.Biol.  4 : 700 - 707

PubMed: 18849972
DOI: 10.1038/nchembio.115

Reaction

Chain : A, B
UniProt : P29477 (NOS2_MOUSE)
Reaction: EC: Evidence:
Physiological Direction:
H(+) + 2 L-arginine + 3 NADPH + 4 O2 = 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide 1.14.13.39 UniProtKB:P35228
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