Brand  (β version)

PDB ID: 3E0Q

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Ligands
Code Name Style Show Link
DMS Dimethyl sulfoxide PoSSuM
JFD 6-amino-5-bromo-1,2,3,4-tetrahydropyrimidine-2,4-dione PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3E0Q   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of Schistosoma mansoni purine nucleoside phosphorylase complexed with a novel monocyclic inhibitor
Release Data : 2009-08-18
Compound :
mol_id molecule chains
1 Purine-nucleoside phosphorylase A,B,C
ec: 2.4.2.1
Source :
mol_id organism_scientific organism_common expression_system
1 Schistosoma mansoni  (taxid:6183) Blood fluke Escherichia coli  (taxid:562)
gene: SmPNP
expression_system_strain: DH5alpha
expression_system_vector_type: Plasmid
expression_system_plasmid: pMAL-C2G
Authors : Pereira, H.M., Berdini, V., Ferri, M.R., Cleasby, A., Garratt, R.C.
Keywords : Monocyclic inhibitor, Glycosyltransferase, Transferase
Exp. method : X-RAY DIFFRACTION ( 1.900 Å )
Citation :

Crystal structure of Schistosoma purine nucleoside phosphorylase complexed with a novel monocyclic inhibitor.

Pereira, H.M.,Berdini, V.,Ferri, M.R.  et al.
(2010)  Acta Trop.  114 : 97 - 102

PubMed: 20122887
DOI: 10.1016/j.actatropica.2010.01.010

Structures for the potential drug target purine nucleoside phosphorylase from Schistosoma mansoni causal agent of schistosomiasis.

Pereira, H.D.,Franco, G.R.,Cleasby, A.  et al.
(2005)  J.Mol.Biol.  353 : 584 - 599

PubMed: 16182308
DOI: 10.1016/j.jmb.2005.08.045

Reaction

Chain : A, B, C
UniProt : Q9BMI9 (Q9BMI9_SCHMA)
Reaction: EC: Evidence:
Physiological Direction:
2'-deoxyguanosine + phosphate = 2-deoxy-alpha-D-ribose 1- phosphate + guanine 2.4.2.1 ARBA:ARBA00023929
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2'-deoxyinosine + phosphate = 2-deoxy-alpha-D-ribose 1- phosphate + hypoxanthine 2.4.2.1 ARBA:ARBA00023950
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guanosine + phosphate = alpha-D-ribose 1-phosphate + guanine 2.4.2.1 ARBA:ARBA00023970
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inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine 2.4.2.1 ARBA:ARBA00023918
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