Brand  (β version)

PDB ID: 3DZ4

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
C8M 3-[{[(2r,3s,4r,5r)-5-(6-amino-8-methyl-9h-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}(methyl)amino]propanamid E PoSSuM
PUT 1,4-diaminobutane PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show
PYR Pyruvic acid

Structure summary

Code : 3DZ4   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : Human AdoMetDC with 5'-[(2-carboxamidoethyl)methylamino]-5'-deoxy-8-methyladenosine
Release Data : 2009-03-10
Compound :
mol_id molecule chains synonym
1 S-adenosylmethionine decarboxylase beta chain B AdoMetDC, SamDC, S-adenosylmethionine decarboxylase alpha chain, S-adenosylmethionine decarboxylase beta chain
ec: 4.1.1.50
mol_id molecule chains synonym
2 S-adenosylmethionine decarboxylase alpha chain A AdoMetDC, SamDC, S-adenosylmethionine decarboxylase alpha chain, S-adenosylmethionine decarboxylase beta chain
ec: 4.1.1.50
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: AMD1, AMD
expression_system_strain: JM109
expression_system_vector_type: plasmid
expression_system_plasmid: pQE30
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: AMD1, AMD
expression_system_strain: JM109
expression_system_vector_type: plasmid
expression_system_plasmid: pQE30
Authors : Bale, S., McCloskey, D.E., Pegg, A.E., Secrist III, J.A., Guida, W.C., Ealick, S.E.
Keywords : Complexes of AdoMetDC with 8-substituted ligands, Decarboxylase, Lyase, Pyruvate, S-adenosyl-L-methionine, Spermidine biosynthesis, Zymogen
Exp. method : X-RAY DIFFRACTION ( 1.840 Å )
Citation :

New Insights into the Design of Inhibitors of Human S-Adenosylmethionine Decarboxylase: Studies of Adenine C8 Substitution in Structural Analogues of S-Adenosylmethionine

McCloskey, D.E.,Bale, S.,Secrist III, J.A.  et al.
(2009)  J.Med.Chem.  52 : 1388 - 1407

PubMed: 19209891
DOI: 10.1021/jm801126a

Reaction

Chain : A
UniProt : P17707 (DCAM_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
H(+) + S-adenosyl-L-methionine = CO2 + S-adenosyl 3- (methylsulfanyl)propylamine 4.1.1.50 PubMed:10029540, PubMed:10574985, PubMed:11583147, PubMed:1917972, PubMed:2460457, PubMed:2687270
-