Brand  (β version)

PDB ID: 3DN0

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Ligands
Code Name Style Show Link
CL Chloride ion PoSSuM
F5B 1,2,3,4,5-pentafluorobenzene PoSSuM
HED 2-hydroxyethyl disulfide PoSSuM
PO4 Phosphate ion PoSSuM
Non-standard Residues
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Glycosylation
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Modification
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Structure summary

Code : 3DN0   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Pentafluorobenzene binding in the hydrophobic cavity of T4 lysozyme L99A mutant
Release Data : 2008-11-11
Compound :
mol_id molecule chains synonym
1 Lysozyme A Lysis protein, Muramidase, Endolysin
ec: 3.2.1.17
mutation: C54T, C97A, L99A
Source :
mol_id organism_scientific expression_system
1 Bacteriophage T4  (taxid:10665) Escherichia coli  (taxid:562)
gene: E
Authors : Liu, L., Matthews, B.W.
Keywords : T4 lysozyme, halogen bond, hydrophobic cavity, halogenated benzene, Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase
Exp. method : X-RAY DIFFRACTION ( 1.80 Å )
Citation :

Halogenated benzenes bound within a non-polar cavity in T4 lysozyme provide examples of I...S and I...Se halogen-bonding.

Liu, L.,Baase, W.A.,Matthews, B.W.
(2009)  J.Mol.Biol.  385 : 595 - 605

PubMed: 19014950
DOI: 10.1016/j.jmb.2008.10.086

Reaction

Chain : A
UniProt : P00720 (ENLYS_BPT4)
Reaction: EC: Evidence:
Physiological Direction:
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. 3.2.1.17 HAMAP-Rule:MF_04110, PubMed:4865643
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