Brand  (β version)

PDB ID: 3DCT

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
064 3-[(E)-2-(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(1-methylethyl)isoxazol-4-yl]methoxy}phenyl)ethenyl]benzoic acid PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 3DCT   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION/TRANSCRIPTION ACTIVATOR
Title : FXR with SRC1 and GW4064
Release Data : 2008-08-12
Compound :
mol_id molecule chains synonym
1 Bile acid receptor A Farnesoid X-activated receptor, Farnesol receptor HRR-1, Nuclear receptor subfamily 1 group H member 4, Retinoid X receptor-interacting protein 14, RXR-interacting protein 14
fragment: ligand binding domain, UNP residues 258-486
mol_id molecule chains synonym
2 Nuclear receptor coactivator 1 B Steroid receptor coactivator 1, SRC-1
ec: 2.3.1.48
fragment: UNP residues 741-761
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: NR1H4, BAR, FXR, HRR1, RIP14
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pRSETa
mol_id organism_scientific
2
synthetic: yes
other_details: Synthetic
Authors : Williams, S.P., Madauss, K.P.
Keywords : FXR, nuclear receptor, GW4064, alpha-helical sandwich, Activator, Alternative splicing, DNA-binding, Metal-binding, Nucleus, Receptor, Repressor, Transcription regulation, Zinc, Zinc-finger, Acyltransferase, Chromosomal rearrangement, Phosphoprotein, Polymorphism, Proto-oncogene, Transferase, Ubl conjugation, TRANSCRIPTION-TRANSCRIPTION ACTIVATOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.500 Å )
Citation :

Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064.

Akwabi-Ameyaw, A.,Bass, J.Y.,Caldwell, R.D.  et al.
(2008)  Bioorg.Med.Chem.Lett.  18 : 4339 - 4343

PubMed: 18621523
DOI: 10.1016/j.bmcl.2008.06.073

Reaction

Chain : A
UniProt : Q96RI1 (NR1H4_HUMAN)
Reaction : -
Chain : B
UniProt : Q15788 (NCOA1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L- lysyl-[protein] 2.3.1.48 -
-