Het-PDB Navi2 (PDB: 3DAJ)

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Ligands
Code	Name		Style	Show	Link
FXG	N-butyl-3-{[6-(9h-purin-6-ylamino)hexanoyl]amino}benzamide				PoSSuM

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Download interaction data: 3DAJ

Code :

3DAJ PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Crystal structure of Aurora A complexed with an inhibitor discovered through site-directed dynamic tethering

Release Data :

2008-07-08

Compound :

mol_id	molecule	chains	synonym
1	serine/threonine kinase 6	A	Aurora-A
	mutation: N173G, K227R, T287D, M289L

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Mus musculus (taxid:10090)	Mouse	Escherichia coli
	gene: Aurka, Stk6

Authors :

He, M.M.

Keywords :

Protein-small molecule inhibitor complex, Kinase, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 2.00 Å )

Citation :

Discovery of an Aurora kinase inhibitor through site-specific dynamic combinatorial chemistry.

Cancilla, M.T.,He, M.M.,Viswanathan, N. et al.
(2008) Bioorg.Med.Chem.Lett. 18 : 3978 - 3981

PDB ID: 3DAJ