Brand  (β version)

PDB ID: 3D3V

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Ligands
Code Name Style Show Link
GOL Glycerol PoSSuM
Non-standard Residues
Code Name Show
F2F 3,4-difluoro-L-phenylalanine
Glycosylation
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Modification
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Structure summary

Code : 3D3V   PDBj   RCSB PDB   PDBe
Header : IMMUNE SYSTEM
Title : The complex between TCR A6 and human Class I MHC HLA-A2 with the modified HTLV-1 TAX (Y5(3,4-difluoroPhenylalanine)) peptide
Release Data : 2009-06-16
Compound :
mol_id molecule chains synonym
1 HLA class I histocompatibility antigen, A-2 alpha chain A MHC class I antigen A*2
mol_id molecule chains synonym
2 Beta-2-microglobulin B Beta-2-microglobulin form pI 5.3
mol_id molecule chains
3 Modified HTLV-1 TAX (Y5(3,4-difluoro)F) peptide C
mol_id molecule chains
4 A6 TCR alpha chain D
mol_id molecule chains
5 A6 TCR beta chain E
Source :
mol_id organism_scientific expression_system
1 Homo sapiens  (taxid:9606) Escherichia coli  (taxid:562)
gene: HLA-A, HLAA
expression_system_strain: BL21
expression_system_vector_type: Plasmid
expression_system_plasmid: pHN1
mol_id organism_scientific expression_system
2 Homo sapiens  (taxid:9606) Escherichia coli  (taxid:562)
gene: B2M, CDABP0092, HDCMA22P
mol_id organism_scientific
3
synthetic: yes
other_details: Sequence from viral protein HTLV-1 TAX. The peptide is commercially available
mol_id organism_scientific expression_system
4 Homo sapiens  (taxid:9606) Escherichia coli  (taxid:562)
mol_id organism_scientific expression_system
5 Homo sapiens  (taxid:9606) Escherichia coli  (taxid:562)
Authors : Borbulevych, O.Y., Clemens, J.R., Baker, B.M.
Keywords : HTLV-1 TAX peptide, 3, 4-difluoroPhenylalanine, MHC class I, HLA-A2, T-cell receptor A6, Glycoprotein, Host-virus interaction, Immune response, Membrane, MHC I, Phosphoprotein, Transmembrane, Immunoglobulin domain, Secreted, Disease mutation, Glycation, Pyrrolidone carboxylic acid, IMMUNE SYSTEM
Exp. method : X-RAY DIFFRACTION ( 2.80 Å )
Citation :

Fluorine substitutions in an antigenic peptide selectively modulate T-cell receptor binding in a minimally perturbing manner.

Piepenbrink, K.H.,Borbulevych, O.Y.,Sommese, R.F.  et al.
(2009)  Biochem.J.  423 : 353 - 361

PubMed: 19698083
DOI: 10.1042/BJ20090732

Reaction

Chain : A
UniProt : P01892
Reaction : -
Chain : B
UniProt : P61769 (B2MG_HUMAN)
Reaction : -