Brand  (β version)

PDB ID: 3CYU

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Ligands
Code Name Style Show Link
0CR Momo-2-[4-(2-(4-(methoxy)-1h-1,2,3-triazol-1-yl)ethyl)benzenesulfonamide]-7,12-bis-[3-(4-(methoxy)-1h-1,2,3-triazol-1-y L)propanoic acid]-cryptophane-a PoSSuM
1CR Popo-2-[4-(2-(4-(methoxy)-1h-1,2,3-triazol-1-yl)ethyl)benzenesulfonamide]-7,12-bis-[3-(4-(methoxy)-1h-1,2,3-triazol-1-yl)propanoic acid]-cryptophane-a PoSSuM
XE Xenon PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Structure summary

Code : 3CYU   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : Human Carbonic Anhydrase II complexed with Cryptophane biosensor and xenon
Release Data : 2008-05-27
Compound :
mol_id molecule chains synonym
1 Carbonic anhydrase 2 A Carbonic anhydrase II, Carbonate dehydratase II, CA-II, Carbonic anhydrase C, CAC
ec: 4.2.1.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: CA2
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
Authors : Aaron, J.A., Jude, K.M., Di Costanzo, L., Christianson, D.W.
Keywords : Zinc metalloenzyme, sulfonamide, cryptophane, xenon, biosensor, Disease mutation, Lyase, Metal-binding
Exp. method : X-RAY DIFFRACTION ( 1.70 Å )
Citation :

Structure of a 129Xe-cryptophane biosensor complexed with human carbonic anhydrase II.

Aaron, J.A.,Chambers, J.M.,Jude, K.M.  et al.
(2008)  J.Am.Chem.Soc.  130 : 6942 - 6943

PubMed: 18461940
DOI: 10.1021/ja802214x

Reaction

Chain : A
UniProt : P00918 (CAH2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
H(+) + hydrogencarbonate = CO2 + H2O 4.2.1.1 PubMed:11327835, PubMed:11802772, PubMed:11831900, PubMed:12056894, PubMed:12171926, PubMed:1336460, PubMed:14736236, PubMed:15300855, PubMed:15453828, PubMed:15667203, PubMed:15865431, PubMed:16106378, PubMed:16214338, PubMed:16290146, PubMed:16686544, PubMed:16759856, PubMed:16807956, PubMed:17127057, PubMed:17251017, PubMed:17314045, PubMed:17330962, PubMed:17346964, PubMed:17540563, PubMed:17588751, PubMed:17705204, PubMed:18024029, PubMed:18162396, PubMed:18266323, PubMed:18374572, PubMed:18481843, PubMed:18618712, PubMed:18640037, PubMed:18942852, PubMed:1909891, PubMed:1910042, PubMed:19170619, PubMed:19186056, PubMed:19206230, PubMed:19520834, PubMed:19778001, PubMed:7761440, PubMed:7901850, PubMed:8218160, PubMed:8262987, PubMed:8399159, PubMed:8451242, PubMed:8485129, PubMed:8639494, PubMed:9265618, PubMed:9398308
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urea = cyanamide + H2O 4.2.1.69 PubMed:10550681, PubMed:11015219
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