Het-PDB Navi2 (PDB: 3CKR)

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Ligands
Code	Name		Style	Show	Link
009	(4s)-1,4-dibenzyl-N-[(1s,2r)-1-benzyl-3-{[3-(dimethylamino)benzyl]amino}-2-hydroxypropyl]-2-oxoimidazolidine-4-carboxamide				PoSSuM

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Download interaction data: 3CKR

Code :

3CKR PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Crystal structure of BACE-1 in complex with inhibitor

Release Data :

2008-06-03

Compound :

mol_id	molecule	chains	synonym
1	Beta-secretase 1	A,B,C	Beta-site APP cleaving enzyme 1, Beta-site amyloid precursor protein cleaving enzyme 1, Membrane-associated aspartic protease 2, Memapsin-2, Aspartyl protease 2, Asp 2, ASP2
	ec: 3.4.23.46 fragment: protease domain, UNP residues 43-454 mutation: R-6K, R-5K

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens	Human	Escherichia coli

Authors :

Min, K.

Keywords :

beta-secretase, aspartyl protease, Alternative splicing, Glycoprotein, Hydrolase, Membrane, Transmembrane, Zymogen

Exp. method :

X-RAY DIFFRACTION ( 2.700 Å )

Citation :

Synthesis, SAR, and X-ray structure of human BACE-1 inhibitors with cyclic urea derivatives

Park, H.,Min, K.,Kwak, H.-S. et al.
(2008) Bioorg.Med.Chem.Lett. 18 : 2900 - 2904

Chain :

A, B, C

UniProt :

P56817 (BACE1_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-\|- Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein.	3.4.23.46	PubMed:10677483
	-	PubMed:10677483

PDB ID: 3CKR