Brand  (β version)

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
JNO 2-{4-[(4-imidazo[1,2-a]pyridin-3-ylpyrimidin-2-yl)amino]piperidin-1-yl}-N-methylacetamide
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show
Code : 3CGO   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : IRAK-4 Inhibitors (Part II)- A structure based assessment of imidazo[1,2 a]pyridine binding
Release Data : 2008-06-03
Compound :
mol_id molecule chains synonym
1 Mitogen-activated protein kinase 10 A Stress-activated protein kinase JNK3, c-Jun N-terminal kinase 3, MAP kinase p49 3F12
ec: 2.7.11.24
fragment: Protein kinase domain, UNP residues 40-402
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens Human Escherichia coli
gene: MAPK10, JNK3, JNK3A, PRKM10
Authors : Ceska, T.A., Platt, A., Fortunato, M., Dickson, K.M., Beevers, R.
Keywords : JNK3 kinase, Inhibitor, Alternative splicing, ATP-binding, Chromosomal rearrangement, Cytoplasm, Epilepsy, Nucleotide-binding, Phosphoprotein, Serine/threonine-protein kinase, Transferase
Exp. method : X-RAY DIFFRACTION ( 3.00 Å )
Citation :

IRAK-4 inhibitors. Part II: A structure-based assessment of imidazo[1,2-a]pyridine binding

Buckley, G.M.,Ceska, T.A.,Fraser, J.L.  et al.
(2008)  Bioorg.Med.Chem.Lett.  18 : 3291 - 3295

PubMed: 18482836
DOI: 10.1016/j.bmcl.2008.04.039

Chain : A
UniProt : P53779 (MK10_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.24 -
-
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.24 -
-