Brand  (β version)

PDB ID: 3CEN

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Ligands
Code Name Style Show Link
FXA N-(2-(((5-chloro-2-pyridinyl)amino)sulfonyl)phenyl)-4-(2-oxo-1(2h)-pyridinyl)benzamide PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3CEN   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Factor XA in complex with the inhibitor N-(2-(((5-chloro-2-pyridinyl) amino)sulfonyl)phenyl)-4-(2-oxo-1(2H)-pyridinyl)benzamide
Release Data : 2008-05-20
Compound :
mol_id molecule chains synonym
1 COAGULATION FACTOR X, HEAVY CHAIN A Stuart factor, Stuart-Prower factor
ec: 3.4.21.6
fragment: Activated factor Xa heavy chain, UNP residues 235-468
mol_id molecule chains synonym
2 COAGULATION FACTOR X, LIGHT CHAIN L Stuart factor, Stuart-Prower factor
ec: 3.4.21.6
fragment: UNP residues 127-178
Source :
mol_id organism_scientific organism_common
1 Homo sapiens Human
other_details: PROTEOLYTIC CLEAVAGE PRODUCT
mol_id organism_scientific organism_common
2 Homo sapiens Human
other_details: PROTEOLYTIC CLEAVAGE PRODUCT
Authors : Chang, C.-H.
Keywords : glycoprotein, hydrolase, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium-binding, Cleavage on pair of basic residues, EGF-like domain, Gamma-carboxyglutamic acid, Hydroxylation, Polymorphism, Zymogen
Exp. method : X-RAY DIFFRACTION ( 1.60 Å )
Citation :

Structure-Activity Relationships of Anthranilamide-Based Factor Xa Inhibitors Containing Piperidinone and Pyridinone P4 Moieties

Corte, J.R.,Fang, T.,Pinto, D.J.P.  et al.
(2008)  Bioorg.Med.Chem.Lett.  18 : 2845 - 2849

PubMed: 18424044
DOI: 10.1016/j.bmcl.2008.03.092

Reaction

Chain : L
UniProt : P00742 (FA10_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin. 3.4.21.6 -
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