Brand  (β version)

PDB ID: 3C72

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Ligands
Code Name Style Show Link
CA Calcium ion PoSSuM
CX1 N-[(benzyloxy)carbonyl]-L-histidyl-N-methyl-L-phenylalanyl-L-tyrosine PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Structure summary

Code : 3C72   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Engineered RabGGTase in complex with a peptidomimetic inhibitor
Release Data : 2008-07-22
Compound :
mol_id molecule chains synonym
1 Geranylgeranyl transferase type-2 subunit alpha A Geranylgeranyl transferase type II subunit alpha, Rab geranylgeranyltransferase subunit alpha, Rab geranyl-geranyltransferase subunit alpha, Rab GG transferase alpha, Rab GGTase alpha
ec: 2.5.1.60
mol_id molecule chains synonym
2 Geranylgeranyl transferase type-2 subunit beta B Geranylgeranyl transferase type II subunit beta, Rab geranylgeranyltransferase subunit beta, Rab geranyl-geranyltransferase subunit beta, Rab GG transferase beta, Rab GGTase beta
ec: 2.5.1.60
Source :
mol_id organism_scientific organism_common expression_system
1 Rattus norvegicus  (taxid:10116) Rat Escherichia coli  (taxid:562)
gene: Rabggta, Ggta
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pGATEV
mol_id organism_scientific organism_common expression_system
2 Rattus norvegicus  (taxid:10116) Rat Escherichia coli  (taxid:562)
gene: Rabggtb, Ggtb
expression_system_strain: BL21
expression_system_vector_type: plasmid
Authors : Guo, Z., Wu, Y.W., Tan, K.T., Bon, R.S., Guiu-Rozas, E., Delon, C., Nguyen, U.T., Wetzel, S., Arndt, S., Goody, R.S., Blankenfeldt, W., Alexandrov, K., Waldmann, H.
Keywords : peptide inhibitor, Rab prenylation, Metal-binding, Prenyltransferase, Transferase, Phosphoprotein
Exp. method : X-RAY DIFFRACTION ( 2.30 Å )
Citation :

Development of selective RabGGTase inhibitors and crystal structure of a RabGGTase-inhibitor complex.

Guo, Z.,Wu, Y.W.,Tan, K.T.  et al.
(2008)  Angew.Chem.Int.Ed.Engl.  47 : 3747 - 3750

PubMed: 18399557
DOI: 10.1002/anie.200705795

Reaction

Chain : A
UniProt : Q08602 (PGTA_RAT)
Reaction: EC: Evidence:
Physiological Direction:
geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein] 2.5.1.60 PubMed:18756270, PubMed:19894725, PubMed:21520375, PubMed:22963166
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Chain : B
UniProt : Q08603 (PGTB2_RAT)
Reaction: EC: Evidence:
Physiological Direction:
geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein] 2.5.1.60 PubMed:18399557, PubMed:18756270, PubMed:19894725, PubMed:22480322, PubMed:22963166, PubMed:8505342
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