Het-PDB Navi2 (PDB: 3BM6)

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Ligands
Code	Name		Style	Show	Link
C9P	4-(dihydroxyboranyl)-2-({[4-(phenylsulfonyl)thiophen-2-yl]sulfonyl}amino)benzoic acid				PoSSuM

Non-standard Residues
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Download interaction data: 3BM6

Code :

3BM6 PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

AmpC beta-lactamase in complex with a P.carboxyphenylboronic acid

Release Data :

2009-02-17

Compound :

mol_id	molecule	chains	synonym
1	Beta-lactamase	A,B	Cephalosporinase
	ec: 3.5.2.6

Source :

mol_id	organism_scientific	expression_system
1	Escherichia coli (taxid:562)	Escherichia Coli (taxid:562)
	strain: K-12 gene: ampC, ampA expression_system_strain: JM109 expression_system_vector_type: plasmid expression_system_plasmid: POGO295

Authors :

Tondi, D.

Keywords :

AmpC, beta-lactamases, cephalosporinase, serine hydrolase, covalent inhibition, Antibiotic resistance, Periplasm, HYDROLASE

Exp. method :

X-RAY DIFFRACTION ( 2.10 Å )

Citation :

Structural study of phenyl boronic acid derivatives as AmpC beta-lactamase inhibitors.

Tondi, D.,Calo, S.,Shoichet, B.K. et al.
(2010) Bioorg.Med.Chem.Lett. 20 : 3416 - 3419

Chain :

A, B

UniProt :

P00811 (AMPC_ECOLI)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
a beta-lactam + H2O = a substituted beta-amino acid	3.5.2.6	PROSITE- ProRule:PRU10102
a beta-lactam + H2O = a substituted beta-amino acid	-	PROSITE- ProRule:PRU10102

PDB ID: 3BM6