Brand  (β version)

PDB ID: 3B6Z

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
CO7 S-{(9r,13r,15s)-17-[(2r,3r,4r,5r)-5-(6-amino-9h-purin-9-yl)-3-hydroxy-4-(phosphonooxy)tetrahydrofuran-2-yl]-9,13,15-trihydroxy-10,10-dimethyl-13,15-dioxido-4,8-dioxo-12,14,16-trioxa-3,7-diaza-13,15-diphosphaheptadec-1-yl}(2e)-but-2-enethioate PoSSuM
GOL Glycerol PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 3B6Z   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Lovastatin polyketide enoyl reductase (LovC) complexed with 2'-phosphoadenosyl isomer of crotonoyl-CoA
Release Data : 2008-09-16
Compound :
mol_id molecule chains
1 Enoyl reductase A
Source :
mol_id organism_scientific expression_system
1 Aspergillus terreus  (taxid:33178) Escherichia coli  (taxid:562)
gene: lovC
expression_system_strain: BL21(DE3)
expression_system_vector_type: Plasmid
expression_system_plasmid: pET28b
Authors : Ames, B.D., Smith, P.T., Ma, S.M., Wong, E.W., Xie, X., Vederas, J.C., Tang, Y., Tsai, S.-C.
Keywords : medium-chain reductase, rossmann fold, NADP-binding, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 1.88 Å )
Citation :

Crystal structure and biochemical studies of the trans-acting polyketide enoyl reductase LovC from lovastatin biosynthesis.

Ames, B.D.,Nguyen, C.,Bruegger, J.  et al.
(2012)  Proc.Natl.Acad.Sci.USA  109 : 11144 - 11149

PubMed: 22733743
DOI: 10.1073/pnas.1113029109

Reaction

Chain : A
UniProt : Q9Y7D0 (LOVC_ASPTE)
Reaction: EC: Evidence:
Physiological Direction:
19 H(+) + holo-[lovastatin nonaketide synthase] + 9 malonyl- CoA + 11 NADPH + S-adenosyl-L-methionine = 9 CO2 + 9 CoA + dihydromonacolin L-[lovastatin nonaketide synthase] + 6 H2O + 11 NADP(+) + S-adenosyl-L-homocysteine 2.3.1.161 PubMed:10334994
-