Brand  (β version)

PDB ID: 3AM9

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Ligands
Code Name Style Show Link
BCT Bicarbonate ion PoSSuM
CA Calcium ion PoSSuM
FAD Flavin-adenine dinucleotide PoSSuM
FES Fe2/s2 (inorganic) cluster PoSSuM
FYO 4-[5-(2,6-dioxo-1,2,3,6-tetrahydropyridin-4-yl)-1h-1,2,4-triazol-3-yl]-6-oxo-1,6-dihydropyridine-2-carbonitrile PoSSuM
GOL Glycerol PoSSuM
MOS Dioxothiomolybdenum(VI) ion PoSSuM
MTE Phosphonic acidmono-(2-amino-5,6-dimercapto-4-oxo-3,7,8a,9,10,10a-hexahydro-4h-8-oxa-1,3,9,10-tetraaza-anthracen-7-ylmethyl)ester PoSSuM
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Structure summary

Code : 3AM9   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Complex of bovine xanthine dehydrogenase and trihydroxy FYX-051
Release Data : 2010-11-03
Compound :
mol_id molecule chains synonym
1 Xanthine dehydrogenase/oxidase A,B Xanthine oxidoreductase, Xanthine dehydrogenase, XD, Xanthine oxidase, XO
ec: 1.17.1.4, 1.17.3.2
Source :
mol_id organism_scientific organism_common
1 Bos taurus  (taxid:9913) Bovine
Authors : Matsumoto, K., Okamoto, K., Ashizawa, N., Matsumura, T., Kusano, T., Nishino, T.
Keywords : xanthine oxidoreductase, xanthine dehydrogenase, FYX-051, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.17 Å )
Citation :

FYX-051: A Novel and Potent Hybrid-Type Inhibitor of Xanthine Oxidoreductase

Matsumoto, K.,Okamoto, K.,Ashizawa, N.  et al.
(2011)  J.Pharmacol.Exp.Ther.  336 : 95 - 103

PubMed: 20952484
DOI: 10.1124/jpet.110.174540

Reaction

Chain : A, B
UniProt : P80457 (XDH_BOVIN)
Reaction: EC: Evidence:
Physiological Direction:
H2O + NAD(+) + xanthine = H(+) + NADH + urate 1.17.1.4 PubMed:11005854, PubMed:12421831, PubMed:15148401, PubMed:4352904
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H2O + hypoxanthine + NAD(+) = H(+) + NADH + xanthine 1.17.1.4 PubMed:11005854, PubMed:12421831, PubMed:15148401, PubMed:4352904
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H2O + O2 + xanthine = H2O2 + urate 1.17.3.2 PubMed:11005854, PubMed:12421831, PubMed:15148401, PubMed:4352904
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