Brand  (β version)

PDB ID: 3ZWY

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Ligands
Code Name Style Show Link
AV1 [(2r,3s,4r,5r)-5-(6-amino-8-bromo-9h-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2r,3s,4s)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate PoSSuM
CV1 (2r,3r,4s,5r,13r,14s,15r,16r)-24-amino-18-bromo-3,4,14,15-tetrahydroxy-7,9,11,25,26-pentaoxa-17,19,22-triaza-1-azonia-8 ,10-diphosphapentacyclo[18.3.1.1^2,5^.1^13,16^.0^17,21^]hexacosa-1(24),18,20,22-tetraene-8,10-diolate 8,10-dioxide PoSSuM
Non-standard Residues
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Structure summary

Code : 3ZWY   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal structure of ADP-ribosyl cyclase complexed with 8-bromo-ADP- ribose and cyclic 8-bromo-cyclic-ADP-ribose
Release Data : 2012-08-22
Compound :
mol_id molecule chains synonym
1 ADP-RIBOSYL CYCLASE A,B,C,D,E,F,G,H ADRC, NAD GLYCOHYDROLASE, NAD(+) NUCLEOSIDASE, NADASE
ec: 3.2.2.5
Source :
mol_id organism_scientific organism_common expression_system
1 APLYSIA CALIFORNICA  (taxid:6500) CALIFORNIA SEA HARE PICHIA PASTORIS  (taxid:4922)
expression_system_strain: X-33
expression_system_plasmid: PPICZALPHAA
Authors : Kotaka, M., Graeff, R., Zhang, L.H., Lee, H.C., Hao, Q.
Keywords : HYDROLASE, SUBSTRATE SPECIFICITY
Exp. method : X-RAY DIFFRACTION ( 2.40 Å )
Citation :

Structural Studies of Intermediates Along the Cyclization Pathway of Aplysia Adp-Ribosyl Cyclase.

Kotaka, M.,Graeff, R.,Chen, Z.  et al.
To be Published 

Reaction

Chain : A, B, C, D, E, F, G, H
UniProt : P29241 (NADA_APLCA)
Reaction: EC: Evidence:
Physiological Direction:
NAD(+) = cyclic ADP-beta-D-ribose + H(+) + nicotinamide - PubMed:10861229, PubMed:1650254
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NADP(+) + nicotinate = nicotinamide + nicotinate-adenine dinucleotide phosphate 2.4.99.20 PubMed:16690024
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2'-phospho-cyclic ADP-ribose + nicotinate = nicotinate-adenine dinucleotide phosphate - PubMed:16690024
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