Brand  (β version)

PDB ID: 3ZWN

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Ligands
Code Name Style Show Link
CGR Cyclic guanosine diphosphate-ribose PoSSuM
NGD 3-(aminocarbonyl)-1-[(2r,3r,4s,5r)-5-({[(S)-{[(S)-{[(2r,3s,4r,5r)-5-(2-amino-6-oxo-1,6-dihydro-9h-purin-9-yl)-3,4-dihyd roxytetrahydrofuran-2-yl]methoxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}methyl)-3,4-dihydroxytetrahydrofuran-2- yl]pyridinium PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3ZWN   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal structure of Aplysia cyclase complexed with substrate NGD and product cGDPR
Release Data : 2011-11-30
Compound :
mol_id molecule chains synonym
1 ADP-RIBOSYL CYCLASE A,B ADRC, NAD GLYCOHYDROLASE, NAD(+) NUCLEOSIDASE, NADASE
ec: 3.2.2.5
Source :
mol_id organism_scientific organism_common expression_system
1 APLYSIA CALIFORNICA  (taxid:6500) CALIFORNIA SEA HARE PICHIA PASTORIS  (taxid:4922)
expression_system_strain: X-33
expression_system_plasmid: PPICZALPHAA
Authors : Kotaka, M., Graeff, R., Zhang, L.H., Lee, H.C., Hao, Q.
Keywords : HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.80 Å )
Citation :

Structural Studies of Intermediates Along the Cyclization Pathway of Aplysia Adp-Ribosyl Cyclase.

Kotaka, M.,Graeff, R.,Chen, Z.  et al.
(2012)  J.Mol.Biol.  415 : 514

PubMed: 22138343
DOI: 10.1016/J.JMB.2011.11.022

Reaction

Chain : A, B
UniProt : P29241 (NADA_APLCA)
Reaction: EC: Evidence:
Physiological Direction:
NAD(+) = cyclic ADP-beta-D-ribose + nicotinamide + H(+) - PubMed:10861229, PubMed:1650254
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nicotinate + NADP(+) = nicotinate-adenine dinucleotide phosphate + nicotinamide 2.4.99.20 PubMed:16690024
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2'-phospho-cyclic ADP-ribose + nicotinate = nicotinate-adenine dinucleotide phosphate - PubMed:16690024
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