Brand  (β version)

PDB ID: 3ZPR

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
NA Sodium ion PoSSuM
Y01 Cholesterol hemisuccinate PoSSuM
3WC 4-methyl-2-(piperazin-1-yl) quinoline PoSSuM
2CV Hega-10 PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 3ZPR   PDBj   RCSB PDB   PDBe
Header : MEMBRANE PROTEIN
Title : Thermostabilised turkey beta1 adrenergic receptor with 4-methyl-2-(piperazin-1-yl) quinoline bound
Release Data : 2013-04-03
Compound :
mol_id molecule chains synonym
1 BETA-1 ADRENERGIC RECEPTOR A,B BETA1 ADRENERGIC RECEPTOR, BETA-1 ADRENORECEPTOR, BETA-1 ADRENOCEPTOR, BETA-T
fragment: RESIDUES 33-243,272-368
mutation: YES
other_details: RESIDUES 3-32 AT THE N-TERMINUS AND RESIDUES 244-271 OF THE THIRD INTRACELLULAR LOOP WERE DELETED FROM THE CONSTRUCT. THE CONSTRUCT WAS TRUNCATED AFTER RESIDUE 367 AND A HEXAHIS TAG ADDED.
Source :
mol_id organism_scientific organism_common expression_system
1 MELEAGRIS GALLOPAVO  (taxid:9103) TURKEY TRICHOPLUSIA NI  (taxid:7111)
cell: ERYTHROCYTE
expression_system_common: CABBAGE LOOPER
expression_system_cell_line: High Five
expression_system_vector_type: BACULOVIRUS
expression_system_plasmid: PBACPAK8
Authors : Christopher, J.A., Congreve, M., Dore, A.S., Marshall, F.H., Myszka, D.G., Brown, J., Koglin, M., Tehan, B., Errey, J.C., Tate, C.G., Warne, T.
Keywords : MEMBRANE PROTEIN, GPCR, FRAGMENT SCREENING, ARYL PIPERAZINE, STRUCTURE BASED DRUG DESIGN
Exp. method : X-RAY DIFFRACTION ( 2.7 Å )
Citation :

Biophysical Fragment Screening of the Beta1-Adrenergic Receptor: Identification of High Affinity Aryl Piperazine Leads Using Structure-Based Drug Design.

Christopher, J.,Brown, J.,Dore, A.  et al.
(2013)  J.Med.Chem.  56 : 3446

PubMed: 23517028
DOI: 10.1021/JM400140Q

Reaction

Chain : A, B
UniProt : P07700 (ADRB1_MELGA)
Reaction : -