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Ligands
Code Name Style Show Link
Non-standard Residues
Code Name Show
FTY Deoxy-difluoromethelene-phosphotyrosine
Glycosylation
Code Name Emphasize
Modification
Code Name Show
Code : 3ZMP   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/PEPTIDE
Title : Src-derived peptide inhibitor complex of PTP1B
Release Data : 2014-01-22
Compound :
mol_id molecule chains synonym
1 TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1 A,B PROTEIN-TYROSINE PHOSPHATASE 1B, PTP-1B
ec: 3.1.3.48
fragment: TYROSINE-PROTEIN PHOSPHATASE DOMAIN, RESIDUES 1-321
mutation: YES
mol_id molecule chains synonym
2 PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC C,D SRC-DERIVED PEPTIDE, PROTO-ONCOGENE C-SRC, PP60C-SRC, P60-SRC
ec: 2.7.10.2
fragment: RESIDUES 527-536
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:562)
mol_id organism_scientific organism_common
2 HOMO SAPIENS  (taxid:9606) HUMAN
synthetic: yes
Authors : Temmerman, K., Pogenberg, V., Meyer, C., Koehn, M., Wilmanns, M.
Keywords : HYDROLASE-PEPTIDE COMPLEX, ENZYME INHIBITORS, STRUCTURE-ACTIVITY RELATIONSHIP, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.619 Å )
Citation :

Development of Accessible Peptidic Tool Compounds to Study the Phosphatase Ptp1B in Intact Cells.

Meyer, C.,Hoeger, B.,Temmerman, K.  et al.
(2014)  Acs Chem.Biol.  9 : 769

PubMed: 24387659
DOI: 10.1021/CB400903U

Chain : A, B
UniProt : P18031 (PTN1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate 3.1.3.48 PROSITE- ProRule:PRU10044
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Chain : C, D
UniProt : P12931 (SRC_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.10.2 PROSITE-ProRule:PRU10028, PubMed:14632929, PubMed:19307596, PubMed:21036157, PubMed:35927303, PubMed:7929427, PubMed:8759729, PubMed:9571170
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[Isoform 1]
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]
2.7.10.2 UniProtKB:Q9WUD9
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[Isoform 2]
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]
2.7.10.2 UniProtKB:Q9WUD9
-
[Isoform 3]
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]
2.7.10.2 UniProtKB:Q9WUD9
-