Brand  (β version)

PDB ID: 3ZLS

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Ligands
Code Name Style Show Link
92P 1h-pyrrolo[2,3-B]pyridine-3-carboxylic acid PoSSuM
NA Sodium ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3ZLS   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of MEK1 in complex with fragment 6
Release Data : 2013-05-22
Compound :
mol_id molecule chains synonym
1 DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 A MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1, MAP KINASE KINASE 1, MAPKK 1, MKK1, ERK ACTIVATOR KINASE 1, MAPK/ERK KINASE 1, MEK 1
ec: 2.7.12.2
fragment: RESIDUES 37-383
mutation: YES
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN SPODOPTERA FRUGIPERDA  (taxid:7108)
expression_system_common: FALL ARMYWORM
expression_system_variant: SF21
Authors : Amaning, K., Lowinsky, M., Vallee, F., Steier, V., Marcireau, C., Ugolini, A., Delorme, C., McCort, G., Andouche, C., Vougier, S., Llopart, S., Halland, N., Rak, A.
Keywords : TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.50 Å )
Citation :

The Use of Virtual Screening and Differential Scanning Fluorimetry for the Rapid Identification of Fragments Active Against Mek1.

Amaning, K.,Lowinski, M.,Vallee, F.  et al.
(2013)  Bioorg.Med.Chem.Lett.  23 : 3620

PubMed: 23648182
DOI: 10.1016/J.BMCL.2013.04.003

Reaction

Chain : A
UniProt : Q02750 (MP2K1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) 2.7.12.2 -
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L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) 2.7.12.2 -
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L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+) 2.7.12.2 -
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