Brand  (β version)

PDB ID: 3ZHY

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Ligands
Code Name Style Show Link
FM6 [(1s)-1-(3,4-dichlorophenyl)-3-[oxidanyl(phenylcarbonyl)amino]propyl]phosphonic acid PoSSuM
MN Manganese (II) ion PoSSuM
NDP Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate PoSSuM
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Structure summary

Code : 3ZHY   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Structure of Mycobacterium tuberculosis DXR in complex with a di- substituted fosmidomycin analogue
Release Data : 2013-10-09
Compound :
mol_id molecule chains synonym
1 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE A,B DXP REDUCTOISOMERASE, 1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERASE, 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE SYNTHASE
ec: 1.1.1.267
Source :
mol_id organism_scientific expression_system
1 MYCOBACTERIUM TUBERCULOSIS  (taxid:83332) ESCHERICHIA COLI  (taxid:469008)
strain: H37RV
expression_system_strain: BL21(DE3)
expression_system_variant: STAR
expression_system_vector_type: PLASMID
expression_system_vector: PET101D-TOPO
Authors : Bjorkelid, C., Jansson, A.M., Bergfors, T., Unge, T., Mowbray, S.L., Jones, T.A.
Keywords : OXIDOREDUCTASE, RV2870C, DOXP/MEP PATHWAY, ISPC
Exp. method : X-RAY DIFFRACTION ( 2.30 Å )
Citation :

Dxr Inhibition by Potent Mono- and Disubstituted Fosmidomycin Analogues.

Jansson, A.M.,Wieckowska, A.,Bjorkelid, C.  et al.
(2013)  J.Med.Chem.  56 : 6190

PubMed: 23819803
DOI: 10.1021/JM4006498

The 1.9 A Resolution Structure of Mycobacterium Tuberculosis 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase, a Potential Drug Target.

Henriksson, L.M.,Bjorkelid, C.,Mowbray, S.L.  et al.
(2006)  Acta Crystallogr.,Sect.D  62 : 807

PubMed: 16790937
DOI: 10.1107/S0907444906019196

Structures of Mycobacterium Tuberculosis 1-Deoxy-D-Xylulose- 5-Phosphate Reductoisomerase Provide New Insights Into Catalysis.

Henriksson, L.M.,Unge, T.,Carlsson, J.  et al.
(2007)  J.Biol.Chem.  282 : 19905

PubMed: 17491006
DOI: 10.1074/JBC.M701935200

Design, Synthesis, and X-Ray Crystallographic Studies of Alpha-Aryl Substituted Fosmidomycin Analogues as Inhibitors of Mycobacterium Tuberculosis 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase.

Andaloussi, M.,Henriksson, L.M.,Wieckowska, A.  et al.
(2011)  J.Med.Chem.  54 : 4964

PubMed: 21678907
DOI: 10.1021/JM2000085

Structural Studies on Mycobacterium Tuberculosis Dxr in Complex with the Antibiotic Fr-900098.

Bjorkelid, C.,Bergfors, T.,Unge, T.  et al.
(2012)  Acta Crystallogr.,Sect.D  68 : 134

PubMed: 22281742
DOI: 10.1107/S0907444911052231

Reaction

Chain : A, B
UniProt : P64012
Reaction : -