Brand  (β version)

PDB ID: 3WYJ

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Ligands
Code Name Style Show Link
H78 [1-oxidanyl-2-[3-[3-[[3-[[3-[3-(2-oxidanyl-2,2-diphosphono-ethyl)phenyl]phenyl]sulfamoyl]phenyl]sulfonylamino]phenyl]phenyl]-1-phosphono-ethyl]phosphonic acid PoSSuM
Non-standard Residues
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Structure summary

Code : 3WYJ   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Structure of E. coli undecaprenyl diphosphate synthase in complex with BPH-789
Release Data : 2015-02-04
Compound :
mol_id molecule chains synonym
1 Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) A,B Ditrans,polycis-undecaprenylcistransferase, Undecaprenyl diphosphate synthase, UDS, Undecaprenyl pyrophosphate synthase, UPP synthase
ec: 2.5.1.31
Source :
mol_id organism_scientific expression_system
1 Escherichia coli K-12  (taxid:83333) Escherichia coli  (taxid:562)
strain: K12
gene: b0174, ispU, JW0169, rth, uppS, yaeS
expression_system_strain: Bl21(DE3)
expression_system_vector_type: plasimd
expression_system_plasmid: pET32Ek/LIC
Authors : Gao, J., Ko, T.P., Huang, C.H., Oldfield, E., Guo, R.T.
Keywords : TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.1 Å )
Citation :

Antibacterial drug leads: DNA and enzyme multitargeting.

Zhu, W.,Wang, Y.,Li, K.  et al.
(2015)  J.Med.Chem.  58 : 1215 - 1227

PubMed: 25574764
DOI: 10.1021/jm501449u

Reaction

Chain : A, B
UniProt : P60472 (UPPS_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
8 isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = di- trans,octa-cis-undecaprenyl diphosphate + 8 diphosphate 2.5.1.31 -
-
Cofactor: Evidence: Note:
Mg(2+) ECO:0000269 | PubMed:12756244
ECO:0000269 | PubMed:15044730
Binds 2 magnesium ions per subunit.