Brand  (β version)

PDB ID: 3WXC

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Ligands
Code Name Style Show Link
ZN Zinc ion PoSSuM
C93 3-(4-hydroxypiperidin-1-yl)benzene-1,2-dicarboxylic acid PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3WXC   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Crystal Structure of IMP-1 metallo-beta-lactamase complexed with a 3-aminophtalic acid inhibitor
Release Data : 2014-10-15
Compound :
mol_id molecule chains synonym
1 Beta-lactamase A,B Beta-lactamase IMP-1, Bla-imp protein, Extended-spectrum B-lactamase, IMP-1 class B beta-lactamase, IMP-1 class B metallo-beta-lactamase, IMP-1 metallo-beta-lactmase, Metallo beta lactamase, Metallo-beta-lactamase, Metallo-beta-lactamase IMP-1
ec: 3.5.2.6
Source :
mol_id organism_scientific expression_system
1 Pseudomonas aeruginosa  (taxid:287) Escherichia coli  (taxid:562)
gene: blaIMP-1, bla IMP, bla-imp, blaESP, imp
expression_system_vector_type: plasmid
Authors : Saito, J., Watanabe, T., Yamada, M.
Keywords : lactamase, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.10 Å )
Citation :

X-ray crystallographic analysis of IMP-1 metallo-beta-lactamase complexed with a 3-aminophthalic acid derivative, structure-based drug design, and synthesis of 3,6-disubstituted phthalic acid derivative inhibitors

Hiraiwa, Y.,Saito, J.,Watanabe, T.  et al.
(2014)  Bioorg.Med.Chem.Lett.  24 : 4891 - 4894

PubMed: 25246278
DOI: 10.1016/j.bmcl.2014.08.039

Reaction

Chain : A, B
UniProt : Q79MP6 (Q79MP6_PSEAI)
Reaction: EC: Evidence:
Physiological Direction:
a beta-lactam + H2O = a substituted beta-amino acid 3.5.2.6 ARBA:ARBA00001526, RuleBase:RU361140
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