Brand  (β version)

PDB ID: 3WTI

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Ligands
Code Name Style Show Link
CT4 1-[(2-chloro-1,3-thiazol-5-yl)methyl]-3-methyl-2-nitroguanidine PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3WTI   PDBj   RCSB PDB   PDBe
Header : SIGNALING PROTEIN
Title : Crystal Structure of Lymnaea stagnalis Acetylcholine-Binding Protein Q55R Mutant Complexed with Clothianidin
Release Data : 2015-02-04
Compound :
mol_id molecule chains synonym
1 Acetylcholine-binding protein A,B,C,D,E ACh-binding protein, AchBP
fragment: UNP residues 21-229
mutation: Q55R
Source :
mol_id organism_scientific organism_common expression_system
1 Lymnaea stagnalis  (taxid:6523) Great pond snail Pichia pastoris  (taxid:4922)
expression_system_strain: X-33
expression_system_vector_type: PLASMID
expression_system_plasmid: pPICZ B
Authors : Okajima, T., Ihara, M., Yamashita, A., Oda, T., Matsuda, K.
Keywords : neonicotinoids, nicotinic acetylcholine receptor, clothianidin, acetylcholine binding, SIGNALING PROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.68 Å )
Citation :

Studies on an acetylcholine binding protein identify a basic residue in loop G on the beta 1 strand as a new structural determinant of neonicotinoid actions

Ihara, M.,Okajima, T.,Yamashita, A.  et al.
(2014)  Mol.Pharmacol.  86 : 736 - 746

PubMed: 25267717
DOI: 10.1124/mol.114.094698

Reaction

Chain : A, B, C, D, E
UniProt : P58154 (ACHP_LYMST)
Reaction : -