Brand  (β version)

PDB ID: 3WF7

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Ligands
Code Name Style Show Link
FS9 1-(9h-purin-6-yl)-N-[3-(trifluoromethyl)phenyl]piperidine-4-carboxamide PoSSuM
GOL Glycerol PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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TPO Phosphothreonine
Glycosylation
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Structure summary

Code : 3WF7   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Crystal structure of S6K1 kinase domain in complex with a purine derivative 1-(9H-purin-6-yl)-N-[3-(trifluoromethyl)phenyl]piperidine-4-carboxamide
Release Data : 2014-08-06
Compound :
mol_id molecule chains synonym
1 Ribosomal protein S6 kinase beta-1 A S6K-beta-1, S6K1, 70 kDa ribosomal protein S6 kinase 1, Ribosomal protein S6 kinase I, Serine/threonine-protein kinase 14A, p70 ribosomal S6 kinase alpha
ec: 2.7.11.1
fragment: UNP residues 78-399
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: RPS6KB1
expression_system_common: Fall armyworm
expression_system_vector_type: Baculovirus
Authors : Niwa, H., Shirouzu, M., Yokoyama, S.
Keywords : SERINE/THREONINE PROTEIN KINASE DOMAIN, TRANSFERASE, PHOSPHORYLATION, ATP-BINDING, ZINC-BINDING, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.8500 Å )
Citation :

Crystal structures of the S6K1 kinase domain in complexes with inhibitors

Niwa, H.,Mikuni, J.,Sasaki, S.  et al.
(2014)  J.Struct.Funct.Genom.  15 : 153 - 164

PubMed: 25078151
DOI: 10.1007/s10969-014-9188-8

Reaction

Chain : A
UniProt : P23443 (KS6B1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) 2.7.11.1 PubMed:15899889, PubMed:17936702, PubMed:18952604, PubMed:19085255, PubMed:28178239
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L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) 2.7.11.1 PubMed:17936702, PubMed:18952604, PubMed:19085255, PubMed:28178239
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