Brand  (β version)

PDB ID: 3W6H

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Ligands
Code Name Style Show Link
FLB 1-(2-ethoxyethoxy)-3,5-bis(trifluoromethyl)benzene PoSSuM
ZN Zinc ion PoSSuM
AZM 5-acetamido-1,3,4-thiadiazole-2-sulfonamide PoSSuM
Non-standard Residues
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Structure summary

Code : 3W6H   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : Crystal structure of 19F probe-labeled hCAI in complex with acetazolamide
Release Data : 2013-03-13
Compound :
mol_id molecule chains synonym
1 Carbonic anhydrase 1 A,B Carbonate dehydratase I, Carbonic anhydrase B, CAB, Carbonic anhydrase I, CA-I
ec: 4.2.1.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: CA1
Authors : Takaoka, Y., Kioi, Y., Morito, A., Otani, J., Arita, K., Ashihara, E., Ariyoshi, M., Tochio, H., Shirakawa, M., Hamachi, I.
Keywords : 19F-NMR, Semisynthetic Biosensor, Chemical Biology, LYASE
Exp. method : X-RAY DIFFRACTION ( 2.964 Å )
Citation :

Quantitative Comparison of Protein Dynamics in Live Cells and In Vitro by In-Cell 19F-NMR

Takaoka, Y.,Kioi, Y.,Morito, A.  et al.
To be published 

Reaction

Chain : A, B
UniProt : P00915 (CAH1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
hydrogencarbonate + H(+) = CO2 + H2O 4.2.1.1 PubMed:10550681, PubMed:16506782, PubMed:16686544, PubMed:16807956, PubMed:17127057, PubMed:17314045, PubMed:17407288, PubMed:18618712, PubMed:19186056, PubMed:19206230
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urea = cyanamide + H2O 4.2.1.69 PubMed:10550681
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Cofactor: Evidence: Note:
Zn(2+) ECO:0000269 | PubMed:12009884
ECO:0000269 | PubMed:15299369
ECO:0000269 | PubMed:16506782
ECO:0000269 | PubMed:16870440
ECO:0000269 | PubMed:17314045
ECO:0000269 | PubMed:17407288
ECO:0000269 | PubMed:6430186
ECO:0000269 | PubMed:7932756
ECO:0000269 | PubMed:804171
ECO:0000269 | PubMed:8057362
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