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Ligands
Code Name Style Show Link
ACP Phosphomethylphosphonic acid adenylate ester
CTN 4-amino-1-beta-D-ribofuranosyl-2(1h)-pyrimidinone
Non-standard Residues
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Glycosylation
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Code : 3W34   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Ternary complex of Thermus thermophilus HB8 uridine-cytidine kinase with substrates
Release Data : 2013-12-11
Compound :
mol_id molecule chains synonym
1 Uridine kinase A,B Cytidine monophosphokinase, Uridine monophosphokinase
ec: 2.7.1.48
Source :
mol_id organism_scientific expression_system
1 Thermus thermophilus  (taxid:300852) Escherichia coli  (taxid:562)
strain: HB8
gene: udk, TTHA0578
expression_system_strain: Rosetta(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET 11a
Authors : Tomoike, F., Nakagawa, N., Masui, R., Kuramitsu, S.
Keywords : kinase, nucleoside, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.91 Å )
Citation :

Structural and Biochemical Studies on the Reaction Mechanism of Uridine-Cytidine Kinase

Tomoike, F.,Nakagawa, N.,Kuramitsu, S.  et al.
(2015)  Protein J.  34 : 411 - 420

PubMed: 26510656
DOI: 10.1007/s10930-015-9636-8

Chain : A, B
UniProt : Q5SKR5 (URK_THET8)
Reaction: EC: Evidence:
Physiological Direction:
ATP + uridine = ADP + H(+) + UMP 2.7.1.48 HAMAP-Rule:MF_00551
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ATP + cytidine = ADP + CMP + H(+) 2.7.1.48 HAMAP-Rule:MF_00551
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