Het-PDB Navi2 (PDB: 3W0O)

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Ligands
Code	Name		Style	Show	Link
ADP	Adenosine-5'-diphosphate				PoSSuM
HY0	Hygromycin B variant				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 3W0O

Code :

3W0O PDBj RCSB PDB PDBe

Header :

TRANSFERASE/ANTIBIOTIC

Title :

Crystal structure of a thermostable mutant of aminoglycoside phosphotransferase APH(4)-Ia, ternary complex with ADP and hygromycin B

Release Data :

2013-08-07

Compound :

mol_id	molecule	chains	synonym
1	Hygromycin-B 4-O-kinase	A	APH(4), Hygromycin B phosphotransferase, Hygromycin-B kinase
	ec: 2.7.1.163 mutation: D20G, A118V, S225P, Q226L, T246A

Source :

mol_id	organism_scientific	expression_system
1	Escherichia coli (taxid:562)	Escherichia coli (taxid:562)
	gene: hph

Authors :

Iino, D., Takakura, Y., Fukano, K., Sasaki, Y., Hoshino, T., Ohsawa, K., Nakamura, A., Yajima, S.

Keywords :

phosphotransferase, TRANSFERASE-ANTIBIOTIC complex

Exp. method :

X-RAY DIFFRACTION ( 1.50 Å )

Citation :

Crystal structures of the ternary complex of APH(4)-Ia/Hph with hygromycin B and an ATP analog using a thermostable mutant.

Iino, D.,Takakura, Y.,Fukano, K. et al.
(2013) J.Struct.Biol. 183 : 76 - 85

Chain :

UniProt :

P00557 (KHYB_ECOLX)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
hygromycin B + ATP = 4-O-phosphohygromycin B + ADP + H(+)	2.7.1.163	PubMed:6318654
hygromycin B + ATP = 4-O-phosphohygromycin B + ADP + H(+)	-	PubMed:6318654

PDB ID: 3W0O