Brand  (β version)

PDB ID: 3VNT

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Ligands
Code Name Style Show Link
0JA 2-chloro-3-(1-cyanocyclopropyl)-N-[5-({2-[(cyclopropylcarbonyl)amino][1,3]thiazolo[5,4-B]pyridin-5-yl}oxy)-2-fluorophenyl]benzamide PoSSuM
EDO 1,2-ethanediol PoSSuM
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Structure summary

Code : 3VNT   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Crystal Structure of the Kinase domain of Human VEGFR2 with a [1,3]thiazolo[5,4-B]pyridine derivative
Release Data : 2012-04-11
Compound :
mol_id molecule chains synonym
1 Vascular endothelial growth factor receptor 2 A VEGFR-2, Fetal liver kinase 1, FLK-1, Kinase insert domain receptor, KDR, Protein-tyrosine kinase receptor flk-1
ec: 2.7.10.1
fragment: UNP residues 806-1171
mutation: truncated residues 940-989
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: KDR, FLK1, VEGFR2
expression_system_strain: Sf9
expression_system_vector_type: Baculovirus
expression_system_plasmid: pFastBac
Authors : Oki, H.
Keywords : vegfr2, kinase domain, Tyrosin-protein kinase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.64 Å )
Citation :

Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors. 1. Exploration of [5,6]-fused bicyclic scaffolds

Okaniwa, M.,Hirose, M.,Imada, T.  et al.
(2012)  J.Med.Chem.  55 : 3452 - 3478

PubMed: 22376051
DOI: 10.1021/jm300126x

Reaction

Chain : A
UniProt : P35968 (VGFR2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.10.1 PROSITE-ProRule:PRU10028, PubMed:10037737, PubMed:10102632
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