Brand  (β version)

PDB ID: 3VJI

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Ligands
Code Name Style Show Link
J53 (2s)-2-{4-butoxy-3-[({4-[(3s,5s,7s)-tricyclo[3.3.1.1~3,7~]dec-1-yl]benzoyl}amino)methyl]benzyl}butanoic acid PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3VJI   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION
Title : Human PPAR gamma ligand binding domain in complex with JKPL53
Release Data : 2012-08-29
Compound :
mol_id molecule chains synonym
1 Peroxisome proliferator-activated receptor gamma A,B PPAR-gamma, Nuclear receptor subfamily 1 group C member 3
fragment: UNP RESIDUES 223-504
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: PPARG, NR1C3
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET28A
Authors : Tomioka, D., Kuwabara, N., Hashimoto, H., Sato, M., Shimizu, T.
Keywords : transcription factor, TRANSCRIPTION
Exp. method : X-RAY DIFFRACTION ( 2.61 Å )
Citation :

Peroxisome proliferator-activated receptors (PPARs) have multiple binding points that accommodate ligands in various conformations: phenylpropanoic acid-type PPAR ligands bind to PPAR in different conformations, depending on the subtype.

Kuwabara, N.,Oyama, T.,Tomioka, D.  et al.
(2012)  J.Med.Chem.  55 : 893 - 902

PubMed: 22185225
DOI: 10.1021/jm2014293

Reaction

Chain : A, B
UniProt : P37231 (PPARG_HUMAN)
Reaction : -