Brand  (β version)

PDB ID: 3VI7

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Ligands
Code Name Style Show Link
GSH Glutathione PoSSuM
CBD Cibacron blue PoSSuM
CA Calcium ion PoSSuM
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Structure summary

Code : 3VI7   PDBj   RCSB PDB   PDBe
Header : Isomerase/Isomerase Inhibitor
Title : Human hematopoietic prostaglandin D synthase inhibitor complex structures
Release Data : 2012-04-18
Compound :
mol_id molecule chains synonym
1 Hematopoietic prostaglandin D synthase A,B,C,D H-PGDS, GST class-sigma, Glutathione S-transferase, Glutathione-dependent PGD synthase, Glutathione-requiring prostaglandin D synthase, Prostaglandin-H2 D-isomerase
ec: 5.3.99.2, 2.5.1.18
mutation: N144M/N344M/N544M/N744M
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: HPGDS, GSTS, PGDS, PTGDS2
expression_system_vector_type: plasmid
Authors : Kado, Y., Inoue, T.
Keywords : sigma class glutathione S transferase(GST), isomerase, glutathione S transferase, Ca binding, GSH binding, Prostaglandin H2 binding, Isomerase-Isomerase Inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.0000 Å )
Citation :

Human hematopoietic prostaglandin D synthase inhibitor complex structures

Kado, Y.,Aritake, K.,Uodome, N.  et al.
(2012)  J.Biochem.  151 : 447 - 455

PubMed: 22418579
DOI: 10.1093/jb/mvs024

Reaction

Chain : A, B, C, D
UniProt : O60760 (HPGDS_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
prostaglandin H2 = prostaglandin D2 5.3.99.2 PubMed:10824118, PubMed:11672424, PubMed:12244105, PubMed:12627223, PubMed:16547010, PubMed:19939518, PubMed:9353279, PubMed:9425264
left-to-right PubMed:10824118, PubMed:12244105
glutathione + RX = a halide anion + an S-substituted glutathione + H(+) 2.5.1.18 PubMed:10824118, PubMed:11672424, PubMed:15113825
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2-glyceryl-prostaglandin H2 = 2-glyceryl-prostaglandin D2 - PubMed:12244105
left-to-right