Het-PDB Navi2 (PDB: 3VGN)

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Ligands
Code	Name		Style	Show	Link
FNN	3-fluoro-4-nitrophenol				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 3VGN

Code :

3VGN PDBj RCSB PDB PDBe

Header :

ISOMERASE

Title :

Crystal Structure of Ketosteroid Isomerase D40N from Pseudomonas putida (pKSI) with bound 3-fluoro-4-nitrophenol

Release Data :

2012-08-22

Compound :

mol_id	molecule	chains	synonym
1	Steroid Delta-isomerase	A,B	Delta(5)-3-ketosteroid isomerase
	ec: 5.3.3.1 mutation: D40N

Source :

mol_id	organism_scientific	expression_system
1	Pseudomonas putida (taxid:303)	Escherichia coli (taxid:562)
	gene: ksi expression_system_strain: BL21 expression_system_vector_type: plasmid

Authors :

Caaveiro, J.M.M., Pybus, B., Ringe, D., Petsko, G.A., Sigala, P.A.

Keywords :

hydrogen bond, KSI, enzyme catalysis, transition state, oxyanion hole, ISOMERASE

Exp. method :

X-RAY DIFFRACTION ( 1.3000 Å )

Citation :

Quantitative dissection of hydrogen bond-mediated proton transfer in the ketosteroid isomerase active site

Sigala, P.A.,Fafarman, A.T.,Schwans, J.P. et al.
(2013) Proc.Natl.Acad.Sci.USA 110 : E2552 - E2561

Chain :

A, B

UniProt :

P07445 (SDIS_PSEPU)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
a 3-oxo-Delta(5)-steroid = a 3-oxo-Delta(4)-steroid	5.3.3.1	-
a 3-oxo-Delta(5)-steroid = a 3-oxo-Delta(4)-steroid	-	-

PDB ID: 3VGN