Het-PDB Navi2 (PDB: 3VF8)

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Ligands
Code	Name		Style	Show	Link
0JE	3-[5-(5-ethoxy-6-fluoro-1h-benzimidazol-2-yl)-1h-pyrazol-4-yl]-1,1-diethylurea				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 3VF8

Code :

3VF8 PDBj RCSB PDB PDBe

Header :

TRANSFERASE/TRANSFERASE INHIBITOR

Title :

Crystal Structure of Spleen Tyrosine Kinase Syk Catalytic Domain with Pyrazolylbenzimidazole Inhibitor 416

Release Data :

2012-05-02

Compound :

mol_id	molecule	chains	synonym
1	Tyrosine-protein kinase SYK	A	Spleen tyrosine kinase
	ec: 2.7.10.2 fragment: unp residues 343-635

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: SYK expression_system_cell_line: SF9 expression_system_vector_type: PLASMID expression_system_plasmid: pFastBac1

Authors :

McLean, L.R., Zhang, Y.

Keywords :

kinase, TRANSFERASE-TRANSFERASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.0800 Å )

Citation :

X-ray crystallographic structure-based design of selective thienopyrazole inhibitors for interleukin-2-inducible tyrosine kinase.

McLean, L.R.,Zhang, Y.,Zaidi, N. et al.
(2012) Bioorg.Med.Chem.Lett. 22 : 3296 - 3300

Chain :

UniProt :

P43405 (KSYK_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]	2.7.10.2	PROSITE-ProRule:PRU10028, PubMed:33782605, PubMed:34634301
	-	PROSITE-ProRule:PRU10028, PubMed:33782605, PubMed:34634301

PDB ID: 3VF8